Hereditary diseases such as hemochromatosis and Wilson disease lead to an accumulation of iron and copper, respectively, in the liver, causing hepatitis.
Hemochromatosis occurs deposit of iron in the tissues due to its excess in the body. One of the main sites of deposit is the liver, which can cause hepatitis.
Wilson's disease is an autosomal recessive hereditary whose main characteristic is the toxic accumulation of copper in tissues, especially the brain and liver, which leads the bearer to manifest neuropsychiatric symptoms and liver disease.
Treatment
There is no cure for inherited diseases that affect the liver. Treatment depends on the disease. For example, treatment of hereditary hemochromatosis involves periodic phlebotomy to remove iron from the body. Wilson's disease is treated with diet and drugs copper (chelants) that eliminate cobre the body and prevent its absorption.
Laboratory tests
A family history of liver disease raises suspicion of an inherited disorder. Meet some useful tests:
• Screening of iron, such as serum iron - The binding capacity of iron and ferritin aid in the diagnosis of hemochromatosis.
• The level of alpha-1-antitripsinal shows the deficiency of the enzyme.
• Dosages of ceruloplasmin and copper are part of the investigation of Wilson's disease in which the blood concentration decreases and increases in ceruloplasmin copper.
• Genetic Testing - Some of these research mutations that can cause certain types of hepatitis. The analysis of mutations in the HFE gene, for example, aid the diagnosis of hemochromatosis.
• Liver biopsy - Microscopic examination of a sample of liver tissue helps in the diagnosis.
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