Cogan's syndrome is a rare rheumatic disease
characterized by inflammation of the ears and eyes. Cogan's syndrome can lead
to vision problems, hearing impairment and dizziness. The situation may also be
associated with an inflammation of the blood vessels (vasculitis called) in
other areas of the body that can cause significant injury of organs or, in a
few cases even death. This disease occurs most often in people aged between 20
and 40 years, and its cause is unknown. However, one theory is that it is an
autoimmune disease in which the body's immune system mistakenly attacks the
tissue of the eyes and ears.
Treatment
An eye disorder may be treated with mild anti-inflammatory drugs, including
steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) that are applied to
the eye. If these agents do not act sufficiently well, oral antibiotics, such
as tetracycline may be recommended in the case of an infection is the cause
ocular inflammation.
In more severe cases may require the use of oral corticosteroids. When large
quantities are required steroids or if the disease is severe and is not
responding to therapy with corticosteroids, are often recommended other
immunosuppressive drugs. These drugs include methotrexate, cyclophosphamide,
cyclosporin or azathioprine. In some cases, combinations of these drugs are
prescribed, and occasionally if the disease has affected blood vessels may be
required surgical intervention to correct the problem.
If excess fluid in the inner ear is causing problems equilibrium, the physician
may prescribe diuretics which increase diuresis and removing body fluids. A
sensation of imbalance can be treated with antihistamines or with
benzodiazepines, such as diazepam and clonazepam or bed rest.
When hearing is impaired and does not improve with medical treatment, it may be
useful to use cochlear implants. These devices are electronic devices that
translate sounds into electrical signals that are transmitted to the brain,
bypassing the ear piece that works poorly. One part of the device is implanted
in the ear and the other part is used outside of it.
If the front of the eye is severely affected by inflammation, a corneal
transplant may improve vision. This surgery replaces the damaged cornea by
another of an organ donor.
Prevention
There is no way to prevent Cogan's syndrome.
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